Assessment of plasma carnitine and acylcarnitine levels in preeclampsia

Objective: carnitine plays a crucial role in fatty acids oxidation. The aim of the study is to assess plasma carnitine and acylcarnitines levels in preeclamptic womedas a measure of abnormal fatty acid oxidation

Methods: the study included 40 women with preeclampsia and 30 normotensive control women in the third trimester of pregnancy. Women with multiple pregnancy, chronic hypertension, diabetes mellitus and renal diseases were excluded. Plasma levels of free carnitine and acylcarnitines were measured with high performance liquid chromatography [HPLC]

results: total and free carnitines and acylcamitines were significantly increased in preeclamptic cases in comparison to the control group. A positive correlation was found between acylcarnitines and diastolic blood pressure [r=0.382, p= 0.018]

Conclusion: the significantly high plasma carnitine concentrations found in this study supports the hypothesis of abnormal fatty acid metabolism in the pathophysiology of preeclampsia. This may contribute to the endothelial cell dysfunction of preeclarnpsia

Comparative study of oral misoprostol versus vaginal misoprostol for induction of second trimesteric abortion

The aim of this work was to compare the safety and efficacy of oral misoprostol with that of vaginal misoprostol for termination of second trimester pregnancy. one hundred twenty women requiring second trimester pregnancy termination were randomly allocated to receive either oral or vaginal misoprostol 400 ug/8 hours, this dose was used for 24 hours after which the attending physician was allowed to either increase dose, decrease frequency of dosing, change route of misoprostol use or use oxytocin, the two groups were comparable with respect to maternal age, parity, indication of abortion and gestational age. Compared with women receiving oral misoprostol, a greater percentage of women receiving vaginal misoprostol aborted within 24 hours [88.33% versus 66.66%]. The induction-abortion interval was significantly shorter in vaginal group [18 +/- 15.5 hours versus 32 + 18 hours, P < 0.001]. Complications namely nausea, vomiting, fever and severe pain were significantly higher in oral misoprostol group. 7 cases [11.66%] in group 1 [Oral misoprostol] shift to vaginal misoprostol after failure to abort within 24 hours from the start of induction. The need for oxytocin augmentation was significantly higher in-group 1[oral misoprostol]. Compared with oral misoprostol, vaginal misoprostol resulted in shorter induction to abortion interval, shorter duration of hospital stay and less side effects from misoprostol